Personality is one of the most important psychological attributes directly influencing the level of Job satisfaction in employees. Some of the studies (e.g. Nicodemus, 2012) affirmed the relationship of different personality type and job satisfaction of employees. In essence, both spirituality and personality lie at the core of human existence (Emmons, 1999). As it is clear that, job satisfaction has very keen association with different personality types and spirituality, still very few studies conducted to find out the relationship between spirituality and its impact on job satisfaction especially has been in India. The present study is conducted on a sample of 100 Government employees in Delhi NCR. The researcher used Big Five Personality Test (McCrae and Costa, 1996), The Spiritual test (Hussain et al. (2011) and Job Satisfaction Scale (Singh and Sharma 2009). A survey method of research design was followed for the entire study. The results of the present study, indicate that there is a negative correlation between Extraversion and Sense of Purpose (r=-0.300*) but there is a positive the correlation between Extraversion and Maintenance of Discipline (r= 0.336*). The study also indicated that except the conscientiousness of the personality, there is no significant difference between male and female participants. The study also indicates that, there is no significant difference between spirituality and job satisfaction levels between male and female participants. From the results of the present study, it can be concluded that people with extraversion, openness and conscientiousness are more satisfied in their job than to the people having neurotic personality. Further, it can be concluded that people with good maintenance spirituality are also more satisfied in their job than to the person having poor maintenance spirituality.