Entrepreneurial self-efficacy (ESE) is most relevant to each individual, particularly those who are in a managerial position. It considers the strength of a person’s belief that he or she will capable of successfully performing the various tasks under any circumstances. The library profession is an administrative responsibility; hence every professional should have the common value of entrepreneurial self-efficacy. The present paper tried to examine the level of ESE among library professionals working in different organizations in Odisha. The study is based on the six dimensions of ESE developed by De Noble et al. (1999). The study is confined to 98 library professionals having a different position in their respective institutions. An assessment is made on the ESE dimension of the library professional to know about their level of ESE. It was found from the analysis that male professionals are more comparison to females and the maximum of the library professionals having a master’s degree and their entrepreneurial self-efficacy (ESE) is very high.