In the face of growing environmental, social, and economic instability, sustainable innovation has become a strategic imperative for organizations operating in volatile, uncertain, complex, and ambiguous (VUCA) environments. This conceptual paper proposes an integrative framework that positions employee mindfulness as a critical antecedent of creativity, emphasizing its role in fostering sustainable innovation and organizational resilience. Drawing from the Self-determination Theory, Broaden-and-Build Theory, Componential Theory of Creativity, Job Demands-Resources Model, and Social Exchange Theory, the framework identifies two mediating pathways—work meaningfulness (cognitive) and workplace happiness (emotional)—through which mindfulness enhances creative capabilities aligned with sustainability goals. The framework lays a foundation for future empirical research and practical interventions aimed at advancing mindful, sustainable innovation across diverse industries.